Publications

Research Papers

1. Krout, D., Pramod, A. B., Dahal, R. A., Tomlinson, M. J., Sharma, B., Foster, J. D., Zou, M.-F., Boatang, C., Newman, A. H., Lever, J. R., Vaughan, R. A., and Henry, L. K. (2017) Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochem. Pharmacol. 10.1016/j.bcp.2017.07.015

2. Krout, D., Rodriquez, M., Brose, S. A., Golovko, M. Y., Henry, L. K. and Thompson, B. J. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8, 1011-1018

3. Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J. and Blakely, R. D. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Br J Pharmacol 

4. Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou M-F, Newman AH, and Khoshbouei H (2016) Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane. Nat Commun 7:10423.

5. Kumar, V., Yarravarapu, N., Lapinsky, D. J., Perley, D., Felts, B., Tomlinson, M. J., Vaughan, R. A., Henry, L. K., Lever, J. R., and Newman, A. H. (2015) Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram. Journal of Medicinal Chemistry 58, 5609–5619 

6. Dahal, R. A., Pramod, A. B., Sharma, B., Krout, D., Foster, J. D., Cha, J. H., Cao, J., Newman, A. H., Lever, J. R., Vaughan, R. A., and Henry, L. K. (2014) Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site. Journal of Biological Chemistry 289, 29712–29727

7.  Bowton, E., Saunders, C., Reddy, I. A., Campbell, N. G., Hamilton, P. J., Henry, L. K., Coon, H., Sakrikar, D., Veenstra-VanderWeele, J. M., Blakely, R. D., Sutcliffe, J., Matthies, H. J. G., Erreger, K., and Galli, A. (2014) SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry 4, e464

8. Felts, B., Pramod, A. B., Sandtner, W., Burbach, N., Bulling, S., Sitte, H. H., and Henry, L. K. (2014) The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. Journal of Biological Chemistry 289, 1825-1840

9. Gaffaney, J. D., Shetty, M., Felts, B., Pramod, A. B., Foster, J. D., Henry, L. K., and Vaughan, R. A. (2013) Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. Neurochem Int 73, 16–26

10. Beckman, M. L., Pramod, A. B., Perley, D., and Henry, L. K. (2013) Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochem Int 73, 98–106.

11. Thompson, B. J., Jessen, T., Henry, L. K., Field, J. R., Gamble, K. L., Gresch, P. J., Carneiro, A. M., Horton, R. E., Chisnell, P. J., Belova, Y., McMahon, D. G., Daws, L. C., and Blakely, R. D. (2011) Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences 108, 3785-3790

12. Henry, L. K., Iwamoto, H., Field, J. R., Kaufmann, K., Dawson, E. S., Jacobs, M. T., Adams, C., Felts, B., Zdravkovic, I., Armstrong, V., Combs, S., Solis, E., Rudnick, G., Noskov, S. Y., DeFelice, L. J., Meiler, J., and Blakely, R. D. (2011) A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. Journal of Biological Chemistry 286, 30823-30836

13. Field, J. R., Henry, L. K., and Blakely, R. D. (2010) Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine. Journal of Biological Chemistry 285, 11270-11280

14. Kaufmann, K. W., Dawson, E. S., Henry, L. K., Field, J. R., Blakely, R. D., and Meiler, J. (2009) Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins 74, 630-642

15. Henry, L. K., Field, J. R., Adkins, E. M., Parnas, M. L., Vaughan, R. A., Zou, M.-F., Newman, A. H., and Blakely, R. D. (2006) Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. Journal of Biological Chemistry 281, 2012-2023

16. Henry, L. K., Adkins, E. M., Han, Q., and Blakely, R. D. (2003) Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. Journal of Biological Chemistry 278, 37052-37063

17. Henry, L. K., Khare, S., Son, C., Babu, V. V. S., Naider, F., and Becker, J. M. (2002) Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photoaffinity labeling. Biochemistry 41, 6128-6139

18. Naider, F., Lee, B. K., Henry, L. K., Ding, F., Khare, S., and Becker, J. M. (2001) Probing the Binding Site of a Heptahelical Peptide Pheromone Receptor Using Photoaffinity Labelling, Site-Directed Mutagenesis and Spectroscopic Approaches. in International peptide symposium 

19. Munro, C. A., Winter, K., Buchan, A., Henry, L.K., Becker, J. M., Brown, A. J., Bulawa, C. E., and Gow, N. A. (2001) Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol Microbiol 39, 1414-1426

20. Bulawa, C. E., Miller, D. W., Henry, L. K., and Becker, J. M. (1995) Attenuated virulence of chitin-deficient mutants of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America 92, 10570-10574


Review Articles

1. Pramod, A. B., Foster, J., Carvelli, L., and Henry, L. K. (2013) SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med 34, 197-219

2. Henry, L. K., and Blakely, R. D. (2008) Distinctions between dopamine transporter antagonists could be just around the bend. Molecular pharmacology 73, 616-618

3. Henry, L. K., Meiler, J., and Blakely, R. D. (2007) Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular interventions 7, 306-309

4. Henry, L. K., Defelice, L. J., and Blakely, R. D. (2006) Getting the message across: a recent transporter structure shows the way. Neuron 49, 791-796

© Keith Henry 2015